a. Knoxville to Memphis via mostly SR 62 following an approximation of the Historic Avery Trace to Nashville, then US 70 toward Memphis but detouring South to connect to US 64 at Waynesboro
b. US 64 from Murphy NC to Memphis except for a detour where US 64 is routed on I-24 for a while.
2. Six North South routes.
a. Follow the Great Valley Route From Bristol to Chattanooga. This would connect with the Northern EW route in Knoxville to give connectivity to Virginia, NC, and GA
b. Celina to Winchester where it would connect with the Ken Kifer route to Alabama
c. Franklin, KY, through Nashville to Ardmore AL
d.Adventure Cycling Great Rivers Route, Land Between the Lakes to Natchez Trace parkway, to AL
e. Adventure Cycling Underground RR, roughly parallels Tennessee River to the Trace in the Land Between the Lakes.
f. Mississippi River Trail
I wouldn't argue with another NS Route between Memphis and Savannah and altering the northern EW route to more closely follow US 70.. I just don't know enough of that region to make a suggestion.